Callyspongynic acid, a polyacetylenic acid which inhibits alpha-glucosidase, from the marine sponge Callyspongia truncata

Yoichi Nakao; Taisuke Uehara; Shigeki Matsunaga; Nobuhiro Fusetani; Rob W M van Soest

doi:10.1021/np0106642

Callyspongynic acid, a polyacetylenic acid which inhibits alpha-glucosidase, from the marine sponge Callyspongia truncata

J Nat Prod. 2002 Jun;65(6):922-4. doi: 10.1021/np0106642.

Authors

Yoichi Nakao¹, Taisuke Uehara, Shigeki Matsunaga, Nobuhiro Fusetani, Rob W M van Soest

Affiliation

¹ Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

PMID: 12088440
DOI: 10.1021/np0106642

Abstract

A new polyacetylenic acid, callyspongynic acid (1), was isolated as an alpha-glucosidase inhibitor from the marine sponge Callyspongia truncata. Its structure was determined by spectroscopic and chemical methods.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetylene / analogs & derivatives
Acetylene / chemistry
Acetylene / isolation & purification*
Acetylene / pharmacology
Alkynes
Animals
Chromatography, Thin Layer
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Esters / chemistry
Esters / isolation & purification
Esters / pharmacology
Glucosidases / antagonists & inhibitors*
Molecular Structure
Netherlands
Nuclear Magnetic Resonance, Biomolecular
Polymers / chemistry
Polymers / isolation & purification*
Polymers / pharmacology
Porifera / chemistry*
Stereoisomerism

Substances

Alkynes
Enzyme Inhibitors
Esters
Polymers
callyspongynic acid
methylcallyspongynate
Glucosidases
Acetylene